包在我身上!! Cayman 脂質藥物傳輸系統-脂肪奈米顆粒
Cayman 脂質藥物傳輸系統-脂肪奈米顆粒
Lipid-based drug delivery (LBDD) system - Lipid nanoparticles (LNPs)
脂肪奈米顆粒(Lipid nanoparticles, LNPs) 為脂質藥物傳輸系統 (lipid-based drug delivery, LBDD) 的其中一員,可以克服藥物穿過細胞膜進入體內,與被免疫系統攻擊的阻礙,且能夠保護不穩定的分子(如:RNA) 進入目標細胞,為潛力極大的藥物遞送載體。
Cayman 提供廣泛的脂質成分、客製化脂質合成和 LNP 開發服務,以及用於 LNP 標靶評估、免疫原性和毒性的工具。
高純度脂質 High-Purity Lipids
陽離子脂質 Cationic & Ionizable Cationic Lipids
陽離子脂質用於包裹核酸並促進LNP 釋放入體內。Ionizable Cationic Lipids 上帶有解離常數 (pKa) 約 6.5 左右的胺基,使其在酸性環境下帶有正電荷,在生理環境下又會變成電中性的狀態,因此能解決表面電荷造成的細胞毒性。以下三個為Cayman 精選的產品並且有經過FDA 認證:
SM-102 - Item No. 33474 (pKa = 6.68)
ALC-0315 - Item No. 34337 (pKa = 6.09)
DLin-MC3-DMA - Item No. 34364 (pKa = 6.44)
Item No. |
Product Name |
37096 |
306-O12B-3 |
36698 |
306Oi10 |
34366 |
93-O17O |
34367 |
93-O17S |
36699 |
C12-200 |
36700 |
cKK-E12 |
36701 |
DLin-DMA |
34363 |
DLin-KC2-DMA |
34364 |
DLin-MC3-DMA |
25726 |
1,2-Dioleoyl-3-dimethylammonium-propane (DODAP) |
15109 |
1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) |
15110 |
1,2-Dioleoyl-3-trimethylammoniumpropane (DOTAP) (chloride) |
35051 |
L-319 |
37122 |
Lipid C24 |
34372 |
Lipid 5 |
35337 |
Lipid 29 |
37652 |
OF-02 |
陰離子脂質 Anionic Lipids
Anionic lipids 可防止保存時LNPs 顆粒的結團。
磷酸絲氨酸 Phosphoserines (PSs)
Item No. |
Product Name |
29983 |
1,2-Dioleoyl-sn-glycero-3-PS (1,2-DOPS) (sodium salt) |
15088 |
1,2-Dipalmitoyl-sn-glycero-3-PS (1,2-DPPS) (sodium salt) |
25847 |
Phosphatidylserine (soy) (sodium salt) |
甘油磷脂 Phosphoglycerols (PGs)
Item No. |
Product Name |
15084 |
1,2-Dilauroyl-sn-glycero-3-PG (1,2-DLPG) (sodium salt) |
15085 |
1,2-Dimyristoyl-sn-glycero-3-PG (1,2-DMPG) (sodium salt) |
20957 |
1,2-Dioleoyl-sn-glycero-3-PG (1,2-DOPG) (sodium salt) |
15086 |
1,2-Dipalmitoyl-sn-glycero-3-PG (1,2-DPPG) (sodium salt) |
25846 |
Phosphatidylglycerol (egg) (sodium salt) |
15105 |
1-Palmitoyl-2-Oleoyl-sn-glycero-3-PG (1,2-POPG) (sodium salt) |
中性磷脂質 Neutral Phospholipids
主要參與膜融合反應,且可用於修飾 LNP 的表面淨電荷
多烯磷脂膽鹼 Phosphocholines (PCs)
Item No. |
Product Name |
15097 |
1,2-Dimyristoyl-sn-glycero-3-PC (1,2-DMPC) |
15098 |
1,2-Dioleoyl-sn-glycero-3-PC (1,2-DOPC) |
10009473 |
1,2-Dipalmitoyl-sn-glycero-3-PC (1,2-DPPC) |
34800 |
Phosphatidylcholine (soy) |
15102 |
1-Palmitoyl-2-Oleoyl-sn-glycero-3-PC (1,2-POPC) |
尿液磷脂醯乙醇胺 Phosphoethanolamines (PEs)
Item No. |
Product Name |
15091 |
1,2-Dioleoyl-sn-glycero-3-PE (1,2-DOPE) |
15092 |
1,2-Dipalmitoyl-sn-glycero-3-PE (1,2-DPPE) |
固醇與膽固醇衍生物Sterol Lipids & Cholesterol Derivatives
提高LNPs 的穩定性並促進膜融合反應,也可以用以提升LNPs 的傳遞。
Item No. |
Product Name |
36187 |
2,3-Oxidosqualene |
25944 |
2H-Cho-Arg (trifluoroacetate salt) |
25943 |
Cho-Arg (trifluoroacetate salt) |
25698 |
Cholesteryl Hemisuccinate |
26439 |
Cholesteryl Myristate |
26471 |
Cholesteryl Nervonate |
26472 |
Cholesteryl Oleate |
16943 |
DC-Chol (hydrochloride) |
26582 |
DMHAPC-Chol |
26583 |
DMPAC-Chol |
26584 |
HAPC-Chol |
26585 |
MHAPC-Chol |
26586 |
OH-Chol |
聚乙二醇化脂質 PEGylated Lipids
可防止LNPs 受到免疫的調理作用攻擊,提高穩定性與生物利用度。Cayman 精選了下列兩個有用在mRNA-based COVID-19 疫苗的產品:
ALC-0159 - Item No. 34336
DMG-PEG(2000) - Item No. 33945
Item No. |
Product Name |
34647 |
CLS-MPEG(2000) |
34649 |
DMPE-MPEG(2000) |
34650 |
DPPE-MPEG(2000) |
26000 |
DSPE-PEG(2000)-amine (sodium salt) |
34272 |
DSPE-PEG(2000) Maleimide (ammonium salt) |
28181 |
DSPE-MPEG(2000) (sodium salt) |
34652 |
DSPE-MPEG(5000) |
LNP Kits
使用LNP Exploration Kits 與LNP Uptake Kits,將 您所需要傳遞的mRNA 或 siRNA 包裹在 LNP 中,無需再額外使用專用設備。
LNP Exploration Kits
Item No. |
Product Name |
35425 |
LNP-102 Exploration Kit |
35426 |
LNP-0315 Exploration Kit |
36970 |
LNP-MC3 Exploration Kit |
LNP Uptake Kits
Item No. |
Product Name |
38218 |
LNP-102 Uptake Kit (Green Fluorescence) |
38219 |
LNP-0315 Uptake Kit (Green Fluorescence) |
偵測核內體逃脫 Monitor Endosomal Escape
當LNPs 藉由胞吞作用送入細胞後,研究者可以藉由以下產品偵測LNPs 送入細胞的效果。
Item No. | Product Name | ||
16221 | Calcein | ||
30752 | Cy5 (triethylamine salt) | ||
10011443 | LAMP-1/CD107a Monoclonal Antibody | ||
25152 | LysoBrite™ Blue |
免疫原性測試 Immunogenicity Assays
當LNPs 進入細胞時,可能會因為被細胞視為外來物,而引發免疫反應與產生細胞毒性,所以需要藉由免疫原性測試與細胞毒性測試來確認LNPs 的安全性。
Immunogenicity Assays
Item No. | Product Name | ||
583301 | Interleukin-1α (human) ELISA Kit | ||
583311 | Interleukin-1β (human) ELISA Kit | ||
501030 | Interleukin-6 (human) ELISA Kit | ||
583371 | Interleukin-6 (mouse) ELISA Kit | ||
501240 | Mouse IgG ELISA Kit |
Cellular & Liver Toxicity Assays
Item No. | Product Name | ||
601170 | LDH Cytotoxicity Assay Kit | ||
701640 | Aspartate Aminotransferase Colorimetric Activity Assay Kit | ||
700260 | Alanine Transaminase Colorimetric Activity Assay Kit |
Luciferase Detection
當LNPs 包裹帶有螢火蟲螢光素酶(firefly luciferase) 報告基因(reporter gene) 的mRNA 時,可以用Luciferase Detection kit 偵測生物活性分布與送入細胞的成效。
Item No. | Product Name | ||||
36495 | INDIGlo Luciferase Detection Reagent Kit | ||||
25836 | D-Luciferin | ||||
20398 | Luciferase (firefly, recombinant) |
更多產品資訊歡迎與 Cayman 台灣獨家代理—昶安生技 洽詢。