抗生素 Antibiotic
抗生素 Antibiotic
| 1. Plasma Membrane Function Disruptors | |
| Ionophores | |
| Ionophores act by transporting Na+ or K+ across the cell membrane, disrupting the transmembrane ion concentration gradient required for proper functioning. | |
| Item No. | Product Name |
| 17457 | Enniatin A1 |
| 9002040 | Enniatin Complex |
| 25742 | Monactin |
| 19447 | Narasin (sodium salt) |
| Polymyxins | |
| Polymyxins are members of a chemically diverse class of non-ribosomal peptides that disrupt outer and inner membrane stability through their cationic properties. | |
| Item No. | Product Name |
| 17584 | Colistin (sulfate) |
| 14157 | Polymyxin B (sulfate) |
| 14074 | Polymyxin B1 |
| 2. Cell Wall Synthesis Inhibitors | |
| β-Lactam Antibiotics | |
| Distinguished by a lactam ring in their molecular structure, these antibiotics act by inhibiting the activity of species- specific membrane-bound penicillin-binding proteins that facilitate cross-linking of the peptidoglycan cell wall. | |
| Penicillins | |
| Item No. | Product Name |
| 19188 | Amoxicillin (hydrate) |
| 14417 | Ampicillin (sodium salt) |
| 20871 | Carbenicillin (sodium salt) |
| 20766 | Piperacillin (sodium salt) |
| Carbapenems | |
| Item No. | Product Name |
| 16934 | Doripenem (hydrate) |
| 20523 | Ertapenem (sodium salt) |
| 16039 | Imipenem (hydrate) |
| 16068 | Meropenem (hydrate) |
| Cephalosporins | |
| Item No. | Product Name |
| 16040 | Cefotaxime (sodium salt) |
| 18866 | Ceftriaxone (sodium salt hydrate) |
| 14828 | Ceftazidime (hydrate) |
| 16127 | Cefsulodin (sodium salt) |
| Glycopeptides & Lipoglycopeptides | |
| These antibiotics form complexes with the C-terminal D-Ala-D-Ala dipeptides in nascent peptidoglycan in Gram-positive bacteria, preventing transglycosylation and transpeptidation reactions during cell wall synthesis. | |
| Item No. | Product Name |
| 21161 | Dalbavancin |
| 15511 | Teicoplanin Complex |
| 15327 | Vancomycin (hydrochloride) |
| Combating Antibiotic Resistance: β-Lactamase Inhibitors | |
| Bacteria develop resistance to β-lactam antibiotics by synthesizing β-lactamase, an enzyme that attacks the β-lactam ring to inactivate the antibiotic. β-Lactamase inhibitors can be used to overcome this resistance. | |
| Item No. | Product Name |
| 22825 | Avibactam (sodium salt) |
| 19456 | Clavulanate (potassium salt) |
| 17185 | Tazobactam (sodium salt) |
| 23962 | Vaborbactam |
| Additional Tunicamycin Derivative & Mixtures | |
| Item No. | Product Name |
| 31537 | TunR1 |
| 28355 | Tunicamycin 14:1 Mixture |
| 28356 | Tunicamycin 15:1 Mixture |
| 28357 | Tunicamycin 16:1 Mixture |
| 28358 | Tunicamycin 17:1 Mixture |
| 11445 | Tunicamycin Mixture |
| 3.Protein Synthesis Inhibitors | |
| Tetracyclines | |
| Tetracyclines bind reversibly to the 30S ribosomal subunit at a position that blocks the binding of the tRNA to the acceptor (A) site on the mRNA-ribosome complex. | |
| Item No. | Product Name |
| 14422 | Doxycycline (hyclate) |
| 14454 | Minocycline (hydrochloride hydrate) |
| 14328 | Tetracycline (hydrochloride) |
| Aminoglycosides | |
| Aminoglycosides bind to the active site of 16S rRNA within the 30S ribosomal subunit, interfering with the accurate recognition of tRNA by rRNA during translation. | |
| Item No. | Product Name |
| 15321 | Kanamycin A (sulfate) |
| 15322 | Kasugamycin (hydrochloride) |
| 16227 | Nourseothricin (sulfate) |
| 14324 | Spectinomycin (hydrochloride hydrate) |
| Macrolides | |
| Macrolide antibiotics interact with 23S rRNA within the 50S ribosomal subunit, blocking the approach to the elongating peptide’s exit tunnel, which results in a premature release of peptidyl-tRNA intermediates. | |
| Item No. | Product Name |
| 15004 | Azithromycin |
| 20587 | PC-766B |
| 19202 | Tulathromycin A |
| 15377 | Venturicidin A |
| Streptogramins | |
| Type A streptogramins block the peptidyl transferase center on the 50S subunit, preventing the earliest event of elongation. Type B streptogramins interfere with the formation of long polypeptides and cause premature detachment of incomplete peptide chains. | |
| Item No. | Product Name |
| 9002172 | Virginiamycin M1 |
| 17455 | Virginiamycin S1 |
| Oxazolidinones | |
| Oxazolidinones bind at the P site of the ribosomal 50S subunit, inhibiting tRNA binding and preventing initiation complex formation. | |
| Item No. | Product Name |
| 15012 | Linezolid |
| Lincosamides | |
| Lincosamides act as structural analogs of portions of tRNA and interrupt peptide chain initiation in the 50S subunit. | |
| Item No. | Product Name |
| 15006 | Clindamycin |
| 20138 | Pirlimycin |
| 4. Nucleic Acid Synthesis Inhibitors | |
| Quinolones | |
| These antibiotics target DNA synthesis by inhibiting bacterial type II topoisomerases (DNA gyrase and topoisomerase IV). | |
| Item No. | Product Name |
| 14286 | Ciprofloxacin (hydrochloride) |
| 17798 | Evitegravir |
| 21047 | Gemifloxacin (mesylate) |
| 14830 | Moxifloxacin (hydrochloride) |
| 25975 | Norfloxacin |
| Rifamycins | |
| Rifamycins are a subclass of ansamycins that bind to bacterial DNA-dependent RNA polymerase and suppress transcription. | |
| Item No. | Product Name |
| 16468 | Rifabutin |
| 14423 | Rifampicin |
| 21441 | Rifamycin SV (sodium salt hydrate) |
| 20307 | Rifapentine |
| 5. Essential Metabolite Synthesis Inhibitors | |
| Sulfonamides | |
| Sulfonamides are structural analogs of 4-aminobenzoic acid that inhibit folate synthesis by targeting dihydropteroate synthase in the folic acid pathway. | |
| Item No. | Product Name |
| 23613 | Sulfamethoxazole |
| 23723 | Sulfanilamide |
| 6. Energy Metabolism Disruptors | |
| Oligomycins | |
| These macrolides form a complex with the oligomycin- sensitivity-conferring protein, which decouples the FO and F1 portions of the mitochondrial ATP synthase complex. | |
| Item No. | Product Name |
| 11341 | Oligomycin Complex |
| 11342 | Oligomycin A |
| 11343 | Oligomycin B |
| 19162 | Oligomycin C |
| 20184 | Oligomycin D |
| 20185 | Oligomycin E |
| Mycobacterial Energy / Metabolism Disruptors | |
| The following three antimycobacterial compounds target type II NADH dehydrogenase, disrupt the proton motive force, and inhibit ATP synthase, respectively. | |
| Item No. | Product Name |
| 23301 | Clofazimine |
| 23416 | Pyrazinamide |
| 20247 | TMC207 |
更多產品資訊，歡迎洽詢 Cayman Chemical 台灣獨家代理 - 昶安科技。
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發佈時間 Dec 01, 2022
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