激酶抑制劑 kinase inhibitor
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激酶 (kinase) 具有調節細胞之間訊號傳遞的生理功能。酵素激酶所建構出的網絡系統 (kinase network)，參與體內所有的生理反應。在基礎實驗與新藥開發等的科研領域中，透過干擾激酶的作用，探究小分子標靶對於生理功能的重要性，開發出最具生理意義的重要小分子。
這篇部落格詳細記錄重要的酵素激酶抑制劑，讓研究者有更多更好的抑制劑選擇，並進一步了解探索激酶在生理功能上的運轉。
| EGFR/ErbB/HER Family | |
| Afatinib | 11492 |
| AZD 9291 | 16237 |
| Erlotinib | 10483 |
| Gefitinib | 13166 |
| Lapatinib | 11493 |
| MEK | |
| AZD 6244 | 11599 |
| BIX02189 | 16999 |
| PD 0325901 | 13034 |
| Trametinib | 16292 |
| U-0126 | 70970 |
| JNK | |
| Bentamapimod | 21482 |
| JNK Inhibitor V | 17542 |
| JNK Inhibitor VIII | 15946 |
| JNK Inhibitor XVI | 18096 |
| SP 600125 | 10010466 |
| IGF-1R | |
| AG-1024 | 14833 |
| BMS 754807 | 17505 |
| Linsitinib | 17708 |
| NVP-AEW541 (hydrochloride) | 13641 |
| Picropodophyllotoxin | 17329 |
| p38 MAPK | |
| Doramapimod | 10460 |
| PD 169316 | 10006727 |
| SB 202190 | 10010399 |
| SB 203580 | 13067 |
| VX-745 | 18075 |
| JAK Family | |
| Baricitinib | 16707 |
| CP 690,550 | 11598 |
| Filgotinib | 17669 |
| Lestaurtinib | 12094 |
| Ruxolitinib | 11609 |
| PI3K | |
| BYL719 | 16986 |
| CAL-101 | 15279 |
| LY294002 | 70920 |
| TGR-1202 | 32877 |
| Wortmannin | 10010591 |
| PKB/Akt | |
| A-443654 | 16499 |
| Akt Inhibitor VIII | 14870 |
| AZD 5363 | 15406 |
| GDC-0068 | 18412 |
| ML-9 | 10010236 |
| ERK | |
| FR180204 | 15544 |
| GDC-0994 | 21107 |
| SCH 772984 | 19166 |
| Ulixertinib (hydrochloride) | 18298 |
| XMD8-92 | 19173 |
| mTOR | |
| AZD 8055 | 16978 |
| PP242 | 13643 |
| Rapamycin | 13346 |
| Torin 1 | 10997 |
| Torin 2 | 14185 |
| PDPK1/PDK1 | |
| BX-795 | 14932 |
| BX-912 | 14708 |
| GSK2334470 | 18095 |
| KT 5720 | 10011011 |
| UCN-01 | 18130 |
| PKC | |
| Calphostin C | 15383 |
| Gö 6976 | 13310 |
| Gö 6983 | 13311 |
| LY333531 (hydrochloride) | 13964 |
| Staurosporine | 81590 |
| IKKs | |
| BMS 345541 (hydrochloride) | 16667 |
| IKK-16 (hydrochloride) | 13313 |
| IKK2 Inhibitor VI | 17276 |
| IMD 0354 | 17290 |
| TPCA-1 | 15115 |
| GSK3 | |
| 1-Azakenpaullone | 16733 |
| BIO | 13123 |
| CHIR99021 | 13122 |
| SB-216763 | 10010246 |
| TWS119 | 10011251 |
| Plks | |
| BI-2536 | 17385 |
| BI-6727 | 18193 |
| GSK461364 | 18099 |
| ON-01910 (sodium salt) | 15553 |
| TAK-960 | 17701 |
| Src | |
| CGP 77675 (hydrate) | 21089 |
| PP1 (Src Inhibitor) | 14244 |
| PP2 | 13198 |
| Saracatinib | 11497 |
| SU6656 | 13338 |
| Abl Family & Bcr-Abl | |
| Bosutinib | 12030 |
| Dasatinib | 11498 |
| Imatinib (mesylate) | 13139 |
| Nilotinib | 10010422 |
| Ponatinib | 11494 |
| CDKs | |
| Dinaciclib | 14707 |
| Flavopiridol (hydrochloride) | 10009197 |
| PD 0322991 (hydrochloride) | 16273 |
| Ro 3306 | 15149 |
| Senexin B | 28459 |
| CSF1R/Fms | |
| BLZ-945 | 19626 |
| Edicotinib | 33347 |
| Ki20227 | 22258 |
| Pexidartinib | 18271 |
| PLX5622 | 28927 |
| ALK (Anaplastic Lymphoma Kinase) | |
| AP26113 | 19778 |
| Ceritinib | 19374 |
| CH5424802 | 18516 |
| PF-06463922 | 18371 |
| TAE684 | 17670 |
| Chk1/2 | |
| AZD 7762 | 11491 |
| CCT241533 (hydrochloride) | 19178 |
| LY2603618 | 20351 |
| LY2606368 | 21490 |
| PF-477736 | 17859 |
| DNA-PK | |
| CC-115 | 19420 |
| Ku-0060648 | 15344 |
| NU 7026 | 13308 |
| NU 7441 | 14881 |
| PI-103 | 10009209 |
| FGFR Family | |
| AZD 4547 | 13111 |
| BGJ398 | 19157 |
| JNJ-42756493 | 21813 |
| PD 173074 | 13032 |
| TAS 120 | 21136 |
| Aurora | |
| AMG 900 | 19176 |
| MLN8237 | 13602 |
| PF-03814735 | 15015 |
| Phthalazionone pyrazole | 10735 |
| ZM 447439 | 13601 |
| c-Met | |
| (R)-Crizotinib | 12087 |
| Golvatinib | 22143 |
| INCB 28060 | 20056 |
| SU11274 | 14861 |
| Tivantinib | 17135 |
| FLT3 | |
| FLT3 Inhibitor III | 21193 |
| Gilteritinib | 21503 |
| Pacritinib | 16709 |
| Quizartinib | 17986 |
| UNC2025 | 16613 |
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發佈時間 May 02, 2022
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